About Portfolio
I'm a Data Scientist and Researcher with a heart full of curiosity and a mind driven by innovation. My journey is about blending data science with biomedical engineering to craft solutions that make a difference in healthcare. With skills in Python, R, MATLAB, and creating user-friendly interfaces and tools, I am passionate about finding new and innovative ways to solve complex problems.
As someone who is dedicated to creating solutions that make a difference, I am excited to bring my expertise to your project. Let's work together to bring your vision to life.
Latest Projects
Tunable FOXM1-D Biosensor Project
The proliferation-associated transcriptional factor forkhead box protein M1 (FoxM1) regulates the expression of G2/M downstream genes which its overexpression has been linked to cancer cell proliferation. Since FoxM1 is generally undetectable throughout the G1 phase of the cell cycle, studies into its functions in some conditions have been limited. In this study, we successfully establish the chemical tunability of the FOXM1 sensor to regulate its expression on desire conditions by adding the degradation induced-dihydrofolate reductase (DHFR) protein to the FOXM1 which will be stabilized by trimethoprim (TMP) in MCF10A cells. We can describe the dynamics of FOXM1 production, degradation, and translocation in G1 and G2 cell cycle phases. Moreover, we can demonstrate the role of FOXM1 in tumorigenesis using this technology. (submitted for publication at doi. 10.1101/2023.03.01.530713v1)
Migration Analytical Platform Project
Wound healing assay is simple and cost-effective in vitro assay for assessing therapeutic impacts on cell migration. Its key limitation is the possible confoundment by other cellular phenotypes, causing misinterpretation of the experimental outcome. In this study, we attempted to address this problem by developing a simple analytical approach for scoring therapeutic influences on both cell migration and cell death, while normalizing the influence of cell growth using Mitomycin C pre-treatment. Finally, we demonstrated a screen for strong pharmaceutical inhibitors of cell migration in cholangiocarcinoma cell lines. Our approach enables accurate scoring of both migrastatic and cytotoxic effects and can be easily implemented for high-throughput drug screening. (doi. 10.1038/s41598-020-57806-0)
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